It is the time of the offseason, as we have done for years here on Cards Wire, where we go through each position and rank players and position groups in the NFC West. We continue by looking at the top running back duos for the Arizona Cardinals, Los Angeles Rams, San Francisco 49ers and Seattle Seahawks.

Not much has changed since last season. The only difference from the start of last season is that the 49ers now have Isaac Guerendo as the primary backup running back instead of Elijah Mitchell or Jordan Mason.

NFL RB duo rankings: NFC West

1. 49ers: Christian McCaffrey, Isaac Guerendo

Based on our starting running back and backup running back rankings, this makes sense. McCaffrey is the top starting back in the division, assuming he has recovered fully from last season’s injuries. Guerendo is the top backup, too. With the top starter and top backup, combined with probably the best running scheme in the league, this makes sense.

2. Cardinals: James Conner, Trey Benson

Conner was third in the starting RB rankings we did behind the Rams‘ Kyren Williams, but it wasn’t by much. He is been a more dynamic and efficient runner than Williams but not as productive. Benson is No. 3 in backups but has starter potential and his production late in the season gives the Cardinals a pairing very similar to the Niners.

3. Seahawks: Kenneth Walker III, Zach Charbonnet

Walker was the lowest-ranked starter but Charbonnet was No. 2 as a backup. Both are productive in the run game and passing game.

4. Rams: Kyren Williams, Blake Corum

Williams had nearly 1,300 yards and rushed for 14 scores but Corum had the lowest rushing production and per-carry average of all the backups. The Rams’ rushing attack was more workhorse than explosive.

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This article originally appeared on Cards Wire: 2025 NFC West RB duo rankings